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Further, it also deactivates the Bcl-2, Bid, and caspase 8 unintentionally and acts against the apoptosis

However, despite the fact that after its discovery, ghrelin was considered a hunger hormone and a regulator of GH secretion in the pituitary, current data indicate that it is a pleiotropic hormone that exerts many different effects on the human body and, therefore, can be produced, as its receptor, in a wide variety of tissues and organs

J Pineal Res (2009) 46(2):1817

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Although its effects on histone acetylation at ATG promoters are not well characterized, HDAC7 is known to silence gene expression through histone deacetylation