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We also observed decreased RAD51 and BRCA1 recruitment to DSBs in cells treated with the IDH1 inhibitor, which was rescued by KG, l-carnitine and acetylcarnitine (Fig

There are three isoforms of CPTI, each present in characteristic tissues, CPTIA in liver and kidney, CPTIB in heart and skeletal muscle and CPTIC in the brain, and while CPTIA and CPTIB are the main enzymes for the transfer of long-chain fatty acids into mitochondria for oxidation, the lesser-known CPTIC may be a sensor of lipid metabolism in neurons

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Tanaka Y, Eda H, Tanaka T, Udagawa T, Ishikawa T, Horii I, Ishitsuka H, Kataoka T, Taguchi T