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Matrix metalloproteinases (MMPs) are up-regulated by pro-inflammatory cytokines, as well as by acute phase proteins like serum amyloid A (SAA), with counter-regulatory inhibition by IL-4 and IL-13, and released into the circulation from damaged vascular endothelium

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Additionally, during the acridine orange (AO) reaction for a lysosome membrane permeability assay, the cells with indicated treatments were stained with 2 g/mL AO (Invitrogen) for 15 min at 37 C

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Narcolepsy is a clinical syndrome of hypothalamic disorder, [10] but the exact cause of narcolepsy is unknown, with potentially several causes

Positive effects have also been reported in the treatment of headaches, fibromyalgia, anxiety, insomnia, and as an anorectic [238,239]