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10.1016/j.biopha.2017.10.125 96 LuoD

6.2 Regulatory and safety assessments GRAS Status: Certain strains, including Lacticaseibacillus rhamnosus GG and Saccharomyces cerevisiae OYR-481 , are recognized as Generally Recognized As Safe (GRAS) by the U.S

Taurine is known to play a significant role in energy metabolism, and dysregulation of taurine levels in these conditions may contribute to the disruption of this process, potentially linking it to the overlapping symptoms observed in both disorders (Wen et al., 2019)

Several factors affect how often B12 injections are needed: The severity of the initial deficiency The presence of neurological symptoms Underlying health conditions affecting B12 absorption The patients response to initial therapy Ongoing monitoring of serum B12 levels By customizing the injection frequency for each patient, we make B12 therapy more effective

As such, we note that differences between the TERLIVAZ and placebo groups in verified HRS reversal, HRS reversal, durability of HRS reversal, verified HRS reversal without HRS recurrence by Day 30, and length of study site hospital stay in days were not statistically significant

& Tully, W