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They revealed that only the benzamide compound BML-210 produced a significant increase of FXN mRNA expression (Herman et al., 2006), although other HDAC inhibitors showed a more pronounced increase of histone acetylation without any increase in FXN expression, indicating a degree of compound specificity for FXN gene silencing (Table 2)

[DOI] [PubMed] [Google Scholar] Stelmach I., Korzeniewska A., Stelmach W., Majak P., Grzelewski T., Jerzynska J

Multiple mechanisms have been suggested for ES in the improvement of nerve regeneration

Patient-derived fibroblasts were used to interpret and analyze the applicability of this approach in a clinically relevant context