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This key role of antioxidants on microbiota probably extends beyond the digestive tract, as the beneficial effect of butyrate has been suggested for other human microbial ecosystems, such as the skin 46 , the gut-brain axis 47 and atopic diseases 48

Pollution, smoking, lack of sleep, poor diet, and UV exposure all increase oxidative stress

doi: 10.1007/s00125-009-1402-z 47 JoJRAnSGhoshSNedumaranBKimYD

Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions

1 2 "Neurotransmitter receptors in the life and death of oligodendrocytes"

doi: 10.3389/fcell.2021.732820 45 MahajanNAroraPSandhirR