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For instance, immunosuppressive cell populations, such as M2-type macrophages, can protect tumor cells from the threat of ferroptosis by secreting antioxidants or directly blocking the ferroptosis signaling pathway ( 3.2 Biological functions of ferroptosis in tumor biology Ferroptosis, as a controlled cell death mechanism, has a prominent impact on the life cycle of digestive tract malignancies

Genetic variants slow this step, causing the flush response

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& Zariwala, M