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Trends Neurosci 20(6):252258 Otto T, Zijlstra FR, Goebel R (2014) Neural correlates of mental effort evaluation-involvement of structures related to self-awareness

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The re-designed multi-particulate formulations were evaluated in an extended phase I study [12], in healthy volunteers with interim pharmacokinetic readout to permit a revision to the dosing regimen for optimal mimicry of the circadian pattern for cortisol