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The effects of NMD on the hypoxia response are neither caused by a general downregulation of HIF-1 activity, nor through HIF-1-dependent regulation of NMD, but instead NMD likely acts in parallel to HIF-1 to co-regulate specific aspects of the hypoxia response

66 MahanamaR.BerenjianA.ValtchevP.TalbotA.BiffinR.RegtopH.et al (2011)

For example, several inorganic nanomaterials, including metal chalcogenide nanoparticles, hybrid metal nanoparticles, and single-atom metal nanoparticles, can act as GSH peroxidase-mimicking nanozymes to exhaust intracellular GSH in cancer cells ( 2 O 2 , realizing tumor-specific catalytic therapy with response to the TME featuring overexpressed GSH and H 2 O 2 (Yin et al., 2019)

GSH-assisted lipotransfer is a promising therapeutic strategy for future clinical application

It is a ubiquitous, evolutionarily conserved intracellular defense mechanism, a master regulator of cytoprotective enzymes that regulates redox metabolism, inflammation, bone remodeling, and detoxification in multiple auto-immune diseases like inflammatory bowel disease and asthma 62

Acta Biomembr