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Therefore, pharmacological agents that inhibit NF-B or p38 MAPK represent a promising class of drugs for repurposing in tinnitus, particularly for prevention in high-risk scenarios or early intervention in acute cases, by broadly suppressing the inflammatory milieu that facilitates the establishment of tinnitus see in Figure 2 , and

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In organotypic hippocampal slice cultures (OHSCs), ferrostatin-1 can prevent neuronal death and reduce hemoglobin-induced iron accumulation, suggesting a pathogenic role for ferroptosis in cerebral hemorrhage [264]