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They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition

Meurer MC, Mees M, Mariano LN, Boeing T, Somensi LB, Mariott M, Dos Santos AC, Longo B, Frana TC, Klein-Jnior LC, de Souza P

Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X

J Surf Sci Technol 27:15 Mohan V, Das A, Sagi I (2020) Emerging roles of ECM remodeling processes in cancer

Future research should prioritize longitudinal human studies that move beyond self-reports to include objective measurements of FKBP51 expression levels and cytokine profiles (e.g., IL-6, TNF-, CRP) to quantify homeostasis restoration. Furthermore, investigations into the potential reversibility of epigenetic patterns, such as DNA methylation of NR3C1 and FKBP5, through long-term cannabinoid therapy are necessary

This allows for tailored combinations of vitamins, minerals, and hydration that may not be achievable through oral supplements alone