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10.1016/j.abb.2008.06.004 Arch Biochem Biophys

Lpez-VicarioCRiusBAlcaraz-QuilesJGarca-AlonsoVLopategiATitosEet alPro-resolving mediators produced from EPA and DHA: overview of the pathways involved and their mechanisms in metabolic syndrome and related liver diseases

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(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder