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Results KAT6A mutations cause a decrease in histone H3 lysine 23 (H3K23) acetylation in human cells and mice To determine the effects of mutation of the KAT6A gene on histone acetylation, we generated human HEK293T cells carrying six different KAT6A variants observed in individuals with ARTHS using CRISPR/Cas9 and homology-directed repair (Tables S1, S2, and S3)

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In all patients, L-Carnitine Rompharm was used in the complex therapy of PD in combination with ADR and levodopa

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Its long been hypothesized Peyronies is caused by penile trauma but that never explained many cases, including the most common version where otherwise perfectly healthy men simply awake with an ugly curve during morning erections