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5.3 Flavanones Flavanones, also called dihydroflavonoids, are defined by a saturated C-ring resulting from the lack of a double bond between C2 and C3

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Given that CRC cells with mutated PIK3CA are more dependent on glutamine, CB-839 (GLS inhibitor) combined with 5-fluorouracil (5-FU) can significantly induce CRC cell apoptosis when compared with the corresponding monotherapies (196)