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This vicious cycle of mtDNA damage accumulation and mitochondrial dysfunction further accelerates neurodegeneration and disease progression

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Crit Rev Toxicol 23:2148 Diplock AT, Rice-Evans AC, Burton RY et al (1994) Is there a significant role of lipid peroxidation in the causation of malignancy and for antioxidants in cancer prevention

Impact of low-density lipoprotein cholesterol on decline in estimated glomerular filtration rate in apparently healthy young to middle-aged working men

In addition, melatonin upregulated the Bcl-2, sirtuin 3, and FOXO type 1 gene expression, as well as downregulated the Bax and caspase-3 gene expression