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Without moderation and a healthy balanced diet, people that drink large amounts of alcohol can become vitamin B12 deficient

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This is the opposite of the intended therapeutic effect

Studies that failed to meet the predefined criteria were excluded from further review

Front Integrative Neurosci 13:48 Li X, Zhu Q, Wang Q, Zhang Q, Zheng Y, Wang L, Jin Q (2020) Protection of sacubitril/valsartan against pathological cardiac remodeling by inhibiting the NLRP3 inflammasome after relief of pressure overload in mice

A single exposure of doxorubicin between 0 and 50 M, yields minimal cytosolic GSH depletion (2.5% maximum decrease), which recovers within the prescribed time-span (Fig