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Stomach acid and intestinal enzymes cleave the peptide into its component amino acids, which then need to be reassembled into glutathione inside cells a process that is inefficient and highly variable

Although siRNA studies show that GSTO1 is important for HCT116 cancer cell viability, knockdown of GSTO1 did not appear to affect C1-27 cytotoxicity, suggesting that other targets of C1-27 also may contribute to its cytotoxicity and have a compensatory effect (Supplementary Fig

By combining fluorescent imaging with proteomics, several VDPs were identified, including thioredoxin reductase 1 (TrxR1), protein disulfide-isomerase (PDI), medium-chain specific acyl-CoA dehydrogenase and malate dehydrogenase (MDH) [95]

M.tb manipulates cAMP signaling pathways within infected macrophages, thereby influencing its survival [107]

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