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Evidence for its role in mitogen-activated protein kinase activation and receptor internalization *

The HIF-1 activation triggers a proangiogenic host cell response with increased levels of vascular endothelial growth factor (VEGF) and up-regulation of genes for the GLUT-3 and glycolytic enzymes (Kempf et al., 2005) thereby inhibiting apoptosis

& Sharma, J

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Cumulative normalized spectral abundance factor (NSAF) value, the index for relative protein abundance for all rabbit (host) proteins in saliva of uninfected and Bb infected nymph ticks was normalized using the z-score statistics and then used to generate heat maps using heatmap2 function in gplots library using R as described in materials and methods