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Fang F, Ni K, Shang J, Zhang X, Xiong C, Meng T

JU received funding from NIHGMS P30GM131944-05S1

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Second, since these enzymes use both acetyl-CoA and lactyl-CoA, Kla inevitably competes (92) or synergizes (75) with Kac at shared lysine residues, raising unresolved questions regarding how these PTMs are selectively regulated

After receptor mice were transplanted with feces from COPD patients for 28 days, they exhibited elevated lung inflammation

Confirmed ORR was 49.0% (95% CI, 39.0 to 59.1) and 56.0% (95% CI, 41.3 to 70.0) and median DoR was 16.8 (95% CI, 6.4 to not estimable) and NR (95% CI, 8.3 to NR) with 5.4 and 6.4 mg/kg, respectively [36]