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It acts primarily by binding to G-actin It prevents it from polymerizing and thus keeping a pool of monomeric actin available for cell motility

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However, other studies suggest that cyclosporin A upregulates gingival SHH (Sonic hedgehog protein) expression in vitro, while in vivo that inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporin A on gingival fibroblast proliferation