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If this delay were to prevent fork damage in pol delta mutant cells, the inhibition of Chk1 would not affect cell viability

Reported mutations in the ATM gene usually involve small deletions and insertions as well as single-nucleotide polymorphisms and lead to a complete absence or impaired function of the protein, mainly observed in sporadic breast cancer and hematological malignancies like T-cell prolymphocytic leukemia and mantle cell lymphoma (Lee 2024)

Sasikumar et al

Affordable Pricing for Long-Term Commitment Exosome infusions are most effective when used continuously

Proc Natl Acad Sci USA 118, e2022857118

The absence of both 5' caps and 3' polyadenylated tails renders circRNAs resistant to exonuclease-mediated degradation, thus ensuring their stability and longevity in cellular processes (158)