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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations BW, body weight

Fonta et al

Use of sentinel lymph node biopsy may aid in identifying patients with occult metastases who might benefit from central neck dissection.[23] Diffuse, intense immunostaining for vascular endothelial growth factor in patients with papillary cancer has been associated with a high rate of local recurrence and distant metastases.[24] An elevated serum thyroglobulin level correlates strongly with recurrent tumor when found in patients with differentiated thyroid cancer during postoperative evaluations.[25,26] Serum thyroglobulin levels are most sensitive when patients are hypothyroid and have elevated serum thyroid-stimulating hormone levels.[27] Expression of the TP53 tumor suppressor gene has also been associated with an adverse prognosis for patients with thyroid cancer.[28] For more information, see the Clinical Features and Prognosis section of the Medullary Thyroid Cancer section and the Clinical Features and Prognosis section of the Anaplastic Thyroid Cancer section

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A daily dose of 0.5 grams/kg for children under 20 kg or a 10-gram dose for those over 20 kg was taken by children in both arms of the study for at least 90 days

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