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Following proper storage guidelines is crucial to keep your medication effective, prevent degradation, and contamination, and avoid any health risks

2021 Dec 1 [cited 2025 Jan 1];13(1_suppl):364S-375S

Full activity consideration begins

Results are typically modest but meaningful when used consistently over time

Routine monitoring discussions should occur if: You have been taking metformin for more than three years without recent B12 testing You are taking high-dose metformin (2g or more daily) You are aged 65 or older You follow a vegan or vegetarian diet You are taking acid-suppressing medications (such as omeprazole or ranitidine) You have other risk factors for B12 deficiency Patients should not commence B12 supplementation without medical advice, as inappropriate supplementation may mask underlying conditions such as pernicious anaemia or other causes of deficiency that require specific investigation and management

The monitoring is precautionary given the limited safety database