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Treatment with this compound did not provoke mastocytosis and actually seemed to reduce total mast cell numbers (40 vs 18 and 8 vs 2 mast cells per mm 2 for digists and knees, in arthritic and nedocromil-treated mice, respectively)

Synopsis Female fertility is impaired by chemotherapy in cancer patients

Figure 4 3.2.3 Ferroptosis-mediated renal interstitial fibrosis Renal interstitial fibrosisan endpoint of CKDis promoted by ferroptosis in AKI models ( Regarding the integrated pathogenic network linking ferroptosis with inflammation, hypoxia, and fibrosis, in this network, the initial AKI-induced tubular injury (e.g., from I/R or nephrotoxicity) directly triggers ferroptosis via mitochondrial dysfunction and iron overload

Bauer JA, Lupica JA, Schmidt H, Morrison BH, Haney RM, et al

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The At LDOX oxidation product was analysed via ESI-MS in positive and negative modes, leading to spectra in accordance with a geminal diol at C3 (Extended Data Fig