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Drug Discov Today 11(1920):931938 Wang Q, Yu X, Li L, Zheng J (2014) Inhibition of amyloid- aggregation in Alzheimers disease

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MOTS-c, as a mitochondrial-derived peptide, offers a unique approach to enhancing cellular energy, improving insulin sensitivity, and counteracting age-related metabolic decline by optimizing foundational cellular processes, particularly through AMPK activation and mitochondrial function

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33 identified that the gut microbe-derived metabolite trimethylamine N-oxide enhanced immunotherapy sensitivity, associated with an immunostimulatory tumor-associated macrophage and activated effector T cell response in the tumor microenvironment

It may achieve this by upregulating vascular endothelial growth factor (VEGF), an endogenous protein responsible for stimulating the growth of new blood vessels [4]