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(1993) Metabolic effects of rhIGF-1 in normal human subjects

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However, the IGF-I gene expression decreased with increasing severity of MASLD, suggesting that reductions of hepatic IGF-I production in patients with MASLD may be related to the severity of the damaged hepatocytes

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thus, the aggregation of mitochondrial enzymes may disrupt the function of these FeS clusters and ultimately lead to cell death