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That is why a better body composition strategy is usually focused on preserving or even improving tissue quality while body fat comes down

10.1021/acs.jafc.4c08428 99 LiuJ.LiuZ.LiX.ZhuL.XuG.ChenZ.et al (2020)

Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response

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However, three major translational barriers persist: (1) Safety concerns from systemic metabolic effectsIDO inhibitors failed to demonstrate survival benefits in phase III trials potentially due to autoimmune toxicity from excessive immune activation