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Depressive episodes are defined by decreased energy, fatigue, pervasive sadness, suicidal thoughts, and cognitive difficulties

As previously discussed, while plants naturally contain melatonin, it is at extremely low levels, making it difficult to obtain sufficient melatonin for therapeutic doses

G.RovinaN.AkinosoglouK.AntoniadouA.AntonakosN.et al (2020)

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To investigate the consequences of individual SBBYSS mutations on KAT6B transcript abundance and histone acetylation, we used CRISPR/Cas9 genome editing and homology-directed repair to generate clonal HEK293T cell lines carrying specific SBBYSS mutations spanning the KAT6B gene, validated by sequencing (Figure 1A and Supplemental Tables 1 and 2

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