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Koeth et al., 2013

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Continually reevaluate patients receiving hydrocodone bitartrate and acetaminophen tablets to assess the maintenance of pain control, signs and symptoms of opioid withdrawal, and other adverse reactions, as well as reassessing for the development of addiction, abuse, or misuse [see WARNINGS]

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However, in order to enhance the capabilities of the GSH-modified GNPs, additional modification strategies are needed

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Limitations : Invasive with risks (e.g., hypoparathyroidism, recurrent laryngeal nerve damage), necessitates lifelong thyroid hormone replacement therapy

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doi: 10.1038/s41467-018-08187-6 95 LiaoSTHanCXuDQFuXWWangJSKongLY

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