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In regard to acoustic signal transduction, this approach is a recent trend in biosensing technologies, and has attracted much attention due to the possibility of refining the signal acquisition and attaining very low limits-of-detection

In biological systems, the nucleophile may be macromolecules, such as nucleic acids (Mller et al., 1998) and proteins (Eyre et al., 1995)

Others are drugs marketed for psychiatric indications, such as ketamine, citalopram, esketamine, N-acetylcysteine, or for neurological conditions like epilepsy, Parkinsons or neuropathic pain (for example, cannabidiol)

doi: 10.1016/0022-510X(90)90004-7 92 EskelinenE.-L

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