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The results were stronger in studies longer than 12 weeks, and doses higher than 2,000mg/day more effectively reduced TNF-alpha.17 Results of a 2023 umbrella meta-analysis on 13 interventional meta-analyses suggest that supplemental doses of L-carnitine of more than 2 g/day can decrease total and LDL-cholesterol and triglycerides, and increase HDL-cholesterol levels

Impaired function of HtrA2 leads to compromised mitochondrial function and increased lactate production [61]

More research is needed to understand whether acetyl-l-carnitine can help patients with the less studied aetiologies, such as infections or trauma

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