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Since cells lose their original epithelial characteristics and acquire some mesenchymal features, then, EMT in cancer cells increases metastasis, invasion and drug resistance rates (103)

Glutathione participates in phase II detoxification by GST-mediated conjugation of electrophiles such as drugs, heavy metals, and lipid peroxides forming mercapturates that are eliminated via MRP/ABCC transporters

However, factors like overall health, metabolism, and post-therapy care significantly influence the treatments effectiveness and outcome

In targeted therapy, GSH depletion prevents redox-driven adaptive resistance to PI3K/AKT/mTOR, MAPK, and KRAS inhibitors, intensifying oxidative stress and restoring drug sensitivity

doi: 10.1042/BSR20211754 99 AborisadeAAkinyeleAAregbesolaBAdesinaOLadejiA

There are even indications it may help with weight loss (or at least, help prevent weight gain) by helping neutralize the toxins which tilt the balance between the two types of fat cells our bodies form after eating: from the white ones, which get stored in our belly because they store energy, and the brown-like ones, which get ear-marked to be burned up to be used as energy