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If the organism becomes resistant to one of the drugs during infection, there is a potential compensatory mechanism in place for the other drug to inhibit growth

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Naunyn Schmiedebergs Arch Pharmacol 391:729742 Nafees S, Rashid S, Ali N, Hasan SK, Sultana S (2015) Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NFB/MAPK pathway

TRIM37 overexpression is associated with chemoresistance in hepatocellular carcinoma via activating the AKT signaling pathway

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High loading capacity was required, making the distinction between dissolved and crystallized drug critical