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CB1, the primary cannabinoid receptor in the nervous system, is one of the most abundantly expressed GPCRs in the CNS and is predominantly found in neurons (Hoffman et al., 2021)

Discovery of a cyclic boronic acid -lactamase inhibitor (RPX7009) with utility vs class A serine carbapenemases

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Together, these shortcomings prevent natural products from reaching the affected brain regions in concentrations sufficient to exert meaningful therapeutic effects 88,89

This reduces the formation of proinflammatory cytokines, such as IL-9 and TNF- and also has vasodilator properties by increasing cyclic GMP levels and by contributing to the regeneration of endothelial-derived relaxing factor