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It has been reported that pretreated animals with NAC or liposomally-entrapped N -acetylcysteine (L- NAC) (25 mg/kg, iv), and challenged with lipopolysaccharide (LPS) ( Escherichia coli , LPS 0111:B4) prevents increased lung weights, decreased lung angiotensin-converting enzyme (ACE) (the injury marker for pulmonary endothelial cells), and significantly reduced the LPS-induced increase in plasma TNF- levels

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