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Physiologically-based TK and population-based TK models account for these factors allowing for the estimation of a range of internal doses that more accurately reflect the diversity of population responses

Subsequently, these endotoxins can exert their effects on the target organs via the circulatory system, leading to further deterioration of the extraintestinal organs and eventually forming a vicious cycle of gut-organ axis disorder, which brings greater challenges to the management of intestinal barrier injury

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There is a strong case that discordance matters

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