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In the case of intrinsic apoptosis, which is mainly associated with mitochondrial dysfunction or ER stress, ROS can activate the cell cycle regulators p53 and JNK, which induce pro-apoptotic Bcl-2 family proteins such as Bak and Baxantagonists to anti-apoptotic proteins Bcl-xL and Bcl-2 in the outer mitochondrial membrane (OMM)eventually causing mitochondrial outer membrane permeabilization and subsequent apoptosis [136, 137]

Pang L, Lian X, Liu H, Zhang Y, Li Q, Cai Y, et al

However, emerging data suggest that different PD therapies exert differential effects on gut microbiota, as shown in Table 4

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Au NPs also decreased GEM resistance in cancer (420)

Cancer Lett 239(2):271280 Huang W-H, Lee A-R, Yang C-H (2006) Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI