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88 Diagnosis Sitosterolemia can be diagnosed by clinical manifestations, a plasma concentration of sitosterol above 1 mg/dL, cerebrotendinous xanthomatosis, and confirmation of ABCG5 and ABCG8 mutations by NGS

Glutamate homeostasis refers to the homeostatic regulation of non-synaptic primarily glial extracellular glutamate by cystineglutamate exchange and glutamate uptake, and the impact of this glutamate on pre- and postsynaptic metabotropic glutamate receptors in terms of regulating synaptic efficiency and plasticity