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& Norgren, S

The evidence for such a decline is strongest in the brain where glutathione loss is implicated in both Parkinsons disease and in neuronal injury following stroke. In fact, aging can result in a deficiency of glutathione, which can then lead to a number of other issues

Recent data has linked xenobiotic exposure to an increased risk for a number of cardiometabolic diseases, including cardiovascular disease, obesity, and diabetes, and it may be that depletion of glutathione levels plays a significant role in this risk, or at the very least can serve as a risk biomarker

PMID 19135374

It is particularly dependent on the activity of several enzymes but this activity can be inhibited rendering these enzymes inactive

Digestive enzymes break down peptides before absorption