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Those exceptional Qualifying variants most likely to be disease related were categorized as Key Qualifying variants, and additionally met at least one of the following categories: Pathogenic or Likely Pathogenic (P/LP) variants: These variants are listed in ClinVar 6 as being either pathogenic (P) or likely pathogenic (LP) for disease

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doi: 10.1007/s00484-014-0829-1 73

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The FASEB Journal, 20 (2), 377-379.