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Description

Low glutathione levels can increase oxidative stress, inflammation, and gut permeability (leaky gut)

2023;5:vdad009

doi: 10.1038/s42003-023-05477-8 115 EberhardYMcDermottSPWangXGrondaMVenugopalAWoodTEet al

Our analysis revealed a surprising overlap between proteins downregulated upon BSO treatment and mitochondrial GSH depletion, suggesting that most of the proteomic changes that occur upon cellular GSH depletion are likely due to mitochondrial effects (Fig