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212 NAMPT inhibition increases Axin expression, which induces -catenin degradation

Xin et al found that the nuclear factor erythroid 2-related factor 2-heme oxygenase-1/glutathione peroxidase 4 axis in DM-associated ED rats was inhibited, leading to ferroptosis and oxidative stress, which impaired endothelial/smooth muscle cell function and further aggravated cavernous fibrosis [92]

10.1016/j.neuroscience.2014.11.048 223 MorettoM

Interestingly, the study also noted striking sex-based differences

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