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A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cysteine uptake leading to glutathione depletion

Remarkably, this simultaneous activation of ISR and OSRpreviously observed only in cancer cellswas shown to occur in normal tissues in mice in the cysteine-restriction group, with the two stress responses reinforcing each other

doi: 10.1016/j.freeradbiomed.2018.01.010 157 ChigbrowMNelsonM

In all cases, REW improved pH-dependent binding to human FcRn (Fig

On the day of infection, THP-1 cells were washed and infected with mycobacteria at an MOI of five, then washed thrice after 4 hours to remove excess bacteria and resuspended in fresh antibiotic-free medium