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These were carried out in rats with occluded major vessel(s), peripherally [129,130,131,132] or centrally [133], which underwent similar noxious procedures [134,135,136,137] and various damaging agent applications [138,139,140,141,142,168]

V(D)J recombination and clonal selection followed by an iterative affinity maturation process results in a broad and flexible B-cell receptor repertoire, eventually giving rise to plasma cells (PCs) that produce the corresponding antibody response [43]