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Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin'

doi:10.1164/rccm.200602-163oc

Nakamura S, Shimazawa M, Hara H (2018) Physiological roles of metallothioneins in central nervous system diseases

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This duality is particularly evident in the intricate process of synaptic transmission (Gopalakrishnan et al., 2010)

They specifically investigated the in vitro induction of eryptosis on healthy RBCs exposed to septic plasma at different time points and evaluated the relationship between eryptosis percentage and Endotoxin Activity Assay (EAA) levels, mortality, and other biological markers of inflammation and oxidative stress [383]