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Although current research has unveiled multiple mechanisms by which TMAO affects cellular function, its specific roles in different tissues and pathological conditions require further investigation

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Other indirect evidence also comes from the coordinated response of enzyme activities and corresponding gene expression that is often observed in response to stress

Sixty-two patients (76.5%) responded to UDCA defined by achieving ALP 3 times baseline levels) were observed in 4 odevixibat-treated patients, but no concurrent TB elevations were observed in these patients

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