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Most roseoflavin-resistant strains studied until now carry mutations in the regulatory region upstream of the rib operon (more specifically, in the aptamer of the riboswitch), disrupting the negative feedback mechanism, resulting in significantly higher expression 184,185

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Nanomaterials 9 , 1131 (2019)

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In Embodiment 21 of this disclosure are compounds of Formula I, or Embodiments 1-11, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 2 is C(O) (C 1-6 )alkyl