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Sauna use increases core temperature, heart rate, blood flow and activates heat shock proteins, all of which support cardiovascular health. Observational evidence (from large population studies) shows that people who use the sauna more frequently have a much lower risk of fatal cardiovascular disease compared to those who use it once per week

However, Epitalon did not prolong the mean lifespan in all groups [84]

In recent work, Lopes and colleagues demonstrated that caffeine increased the energy charge and redox state of cortical synaptosomes, suggesting that this effect led to an increase in the glycolytic rate, thereby enhancing astrocyte-synapse lactate transport

in the other direction

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Crohns Colitis 10 , 495500 (2016)