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Determination of serum biotinidase activity with radioiodinated biotinylamide analogs

At the end of 4 weeks, 24 h urine samples were collected from the metabolism cages before the animals were killed by decapitation

This "fat bubble" protects the nutrient as it passes through the stomach, allowing for much higher absorption

However, diffusion tensor imaging results have not been fully consistent: a longitudinal multicentre study of 423 newly diagnosed PD patients followed-up over 3 years showed no correlation of baseline, or longitudinal diffusion tensor-derived measures with subsequent cognitive impairment 136 , with negative results seen in another independent cohort 137

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