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This process is crucial for energy metabolism, especially during periods of prolonged physical activity or when the body requires an additional energy boost

Schwartzberg, L., Barbour, S

Upon promoter binding, RSV polymerase experiences conformational changes including the stabilization of the supporting helix and the supporting loop as well as subtle inward movement of the PRNTase domain 35 , whereas there is no obvious overall structural remodeling of EBOV polymerase upon the association of the 3-leader 9

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Combination data with diet suggest complementary mechanisms, and reviews highlight continued medicinal-chemistry work to tune potency, selectivity, and exposure for future translational studies